We are the Indiana Biosciences Research Institute (IBRI). We are a leading translational research institute that advances academic and industry science through collaboration to improve patient health outcomes. Building your career at the IBRI in Indianapolis’ 16 Tech Innovation District, means being part of a team of renowned scientists, creative thinkers, and innovative leaders.

Today’s research is being driven by significant advances in our abilities to study complex disease processes and propose new ways to improve patients’ lives. To reflect the evolving nature of life sciences research and encourage synergies through collaboration, we’re enhancing our integrated capabilities, adding depth to how we approach patient-informed translational science and pursuing four foundational areas of scientific focus. These four areas will provide us the core talent and capability to pursue translational science in this new patient-centric framework:

•  Disease, Systems, Pathways – We’re working to better understand diabetes and identify new ways to combat the disease. We’re applying this learning to other diseases that share common systems and pathways.
• Molecular Innovation – We’re developing new capabilities for molecular design and drug discovery to investigate disease processes and pursue new therapeutic approaches.
• Integrated Data Sciences – We’re pursuing advanced data sciences to create novel end-user inspired solutions that address complex analysis, simulation, and prediction across the translational sciences.
• Enabling Technologies – We’re building a rich platform of enabling technologies that give our scientists, partners, and collaborators access to the best tools to solve complex scientific problems.

 The IBRI’s vision is to build a world-class organization of researchers, innovators and business professionals that catalyze activities across the Indiana (and beyond) life sciences community. To achieve that vision, we look for curious and collaborative team members who are energized by innovation, guided by integrity, and inspired by diversity.

The Opportunity

 Our Molecular Innovation area has a research Postdoctoral Fellow position. This role will provide computational chemistry support to multiple multi-disciplinary drug discovery teams focusing on disease areas such as Alzheimer’s disease, metabolic disorders, pediatric oncology, and/or other areas. The opening is partially supported by the federally funded TREAT-AD (TaRget Enablement to Accelerate Therapy Development for Alzheimer’s Disease) drug discovery center, consequently, the candidate will interact with a diverse array of scientists associated with TREAT-AD from outside the IBRI as well.

Key Responsibilities

• Utilize molecular simulation tools to advance drug discovery projects including:
  • Molecular Dynamics
  • Molecular Docking
  • Alchemical Free Energy Calculations
  • Pharmacophore Similarity Comparison Tools
• Perform virtual screening using the above tools.
• Develop workflows using bash, python, SLURM, and other platforms.
• Leverage large-scale computing resources such as the TOP500-ranked Big Red 200 supercomputer to perform calculations at scale.

 Qualifications:

• A PhD in a molecular simulations-based field is required.
• A strong track record of publications, patents, abstract submissions, or other proof of continual professional growth is required.
• The candidate must be proficient in using command line operations on a remote Linux system.
• The candidate must be proficient in python programming, as well as programming in the bash shell.
• Experience with commercial small molecule drug discovery toolkits (Schrodinger Maestro, MOE, SeeSar) is a plus.
• Experience using molecular dynamics programs such as GROMACS, AMBER, or OpenMM is a plus.
• Experience setting up and performing alchemical free energy calculations is a plus.
• Experience in using chemoinformatic tools is a plus.
• Relevant experience in scripting workflows is required.
• Good organization and communication skills are required.

Equal Employment Opportunity:

The IBRI provides equal employment opportunities to all employees and applicants and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.